Immunotherapy uses the body's immune system to recognize and destroy cancer cells. One way to do this is through immune ...

The innate immune response is the body's first line of defense against infection, and a successful immune defense takes a village: a combination of physical barriers, chemical attacks, and an army of ...

It also targets a section of the STING pathway that is necessary for mouse STING signalling, but not humans. This fundamental mechanistic difference explains the discrepancies in inhibitor ...

H-151 is a powerful STING inhibitor because once it binds to its target, it does not let go. It also targets a section of the STING pathway that is necessary for mouse STING signalling, but not ...

The scientists believe the discovery that the STING signaling pathway is directly linked to pain, independently of inflammation, may also apply to other viral and bacterial infections, including ...

The scientists showed that the mutation inhibits the cGAS-STING pathway, an innate immune signaling cascade that is abnormally activated in Alzheimer’s and other neurodegenerative diseases.

Targeting ENPP1 is therefore expected to precisely modulate the STING signaling pathway within tumor tissue, restore local immune activation, and enhance anti-tumor immune responses.

The Weill Cornell Medicine scientists showed that the mutation inhibits the cGAS-STING pathway, an innate immune signaling cascade that is abnormally activated in Alzheimer's and other ...

The STING inhibitor decreased inflammatory factor levels in the cholestatic mouse model, with IL-6 exhibiting the most potent inhibitory effect on OATP1B1. IL-6 downregulated β-catenin/TCF4 ...

A study led by researchers from the University of Michigan showed that targeting CDK12 and a related gene, CDK13, strongly ...