“However, whether the cGAS–STING pathway directly contributes to cellular senescence in human tissues or age-related inflammation and dysfunction in vivo remains unclear,” they noted.

The STING pathway also activates the NF-κB signaling cascade, further promoting inflammation. The STING pathway's role in NAFLD progression is multifaceted.

“The discovery of T EM cell-induced innate inflammation through DNA damage and a non-canonical STING-NF-kB pathway presents this pathway as a potential target to alleviate T cell-driven ...

Different pathways within the cell are activated or silenced dependent on the external signals acting on a cell. One such pathway includes the stimulator of interferon genes (STING) pathway which acts ...

A new study led by Andrea Ablasser at EPFL now shows that a molecular signaling pathway called cGAS/STING, plays a critical role in driving chronic inflammation and functional decline during aging.

To find out if this DNA sensor explains inflammaging, co-first authors Muhammet Gulen and Natasha Samson and colleagues started by testing H-151, a small-molecule STING inhibitor they had developed in ...

More information: Sarah Naguib et al, The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway, Immunity (2025).

A new study led by Andrea Ablasser at EPFL now shows that a molecular signaling pathway called cGAS/STING, plays a critical role in driving chronic inflammation and functional decline during aging.

While short bursts of STING-mediated inflammation are crucial, in some people this pathway is chronically "on," a state that has been linked with neurodegeneration and other diseases of aging, as ...

Launched in February 2019, with a focus on developing small molecules that inhibit the cGAS- STING pathway, the company entered into an option and collaboration agreement with Novartis in ...