“However, whether the cGAS–STING pathway directly contributes to cellular senescence in human tissues or age-related inflammation and dysfunction in vivo remains unclear,” they note ...

While short bursts of STING-mediated inflammation are crucial, in some people this pathway is chronically "on," a state that has been linked with neurodegeneration and other diseases of aging ...

Telomere erosion is a hallmark of aging, yet its downstream mechanisms and impact on organismal aging remain unclear. This ...

In mice gene-edited to lack the STING pathway, that's exactly what they found. When treated with a drug known to induce an intense T cell-mediated inflammatory response, these mice did not produce ...

In mice gene-edited to lack the STING pathway, that’s exactly what they found. When treated with a drug known to induce an intense T cell-mediated inflammatory response, these animals did not ...

Recent research has highlighted the role of the stimulator of interferon genes (STING) signaling pathway in mediating hepatic inflammation and metabolic disorders, making it a potential target for ...

Picking up these signals triggers an inflammatory response. Inappropriate activation of the STING pathway leads to excessive signaling that drives inflammation. IFM Therapeutics says dysregulation ...

With age, mitochondrial DNA leaks into cytosol of microglia. The wayward DNA may set off the inflammatory cGAS-STING pathway. This causes neuronal damage and memory loss in mice. STING inhibitor calms ...

While short bursts of STING-mediated inflammation are crucial, in some people this pathway is chronically "on," a state that has been linked with neurodegeneration and other diseases of aging ...