3 cGAS-STING signaling pathway in chronic inflammatory lung diseases The cGAS-STING signaling pathway not only plays a crucial role in pathogen infections and autoimmune diseases but also ...

“However, whether the cGAS–STING pathway directly contributes to cellular senescence in human tissues or age-related inflammation and dysfunction in vivo remains unclear,” they noted.

The inflammatory response exists universally in almost all physiologic and pathologic progressions. cGAS-STING is pivotal in modulating cellular inflammation, so it is promising to extend our ...

SCOPE OF THE REPORT The “STING Pathway Targeting Therapeutics and Technologies - By Type (Agonist and Antagonist), Molecule (Cyclic Dinucleotides, Non-nucleotides, Live Biotherapeutics, Oncolytic ...

“The discovery of T EM cell-induced innate inflammation through DNA damage and a non-canonical STING-NF-kB pathway presents this pathway as a potential target to alleviate T cell-driven ...

The STING pathway also activates the NF-κB signaling cascade, further promoting inflammation. The STING pathway's role in NAFLD progression is multifaceted.

A study led by Weill Cornell Medicine reveals that the APOE3-R136S mutation delays Alzheimer’s disease by inhibiting the cGAS-STING immune pathway. This mutation suppresses inflammation in ...

STING-dependent sensing of self-DNA drives silica-induced lung inflammation. Nature Communications, 2018; 9 (1) DOI: 10.1038/s41467-018-07425-1 ...

An activated microglial cell in the brain of cGAS/STING activated mice. Credit: Gulen et al. Nature 02 August 2023. DOI: 10.1038/s41586-023-06373-1 ...