Its central role in immunosurveillance positions the cGAS-STING pathway as an attractive anti-cancer immunotherapeutic drug target for chemical agonists or vaccine adjuvants and suggests a key ...

Researchers have been exploring ways to activate the cGAS/STING pathway in tumors as a way to slow their growth.

The cGAS–STING pathway is part of the innate immune system and is involved in the detection of cytosolic deoxyribonucleic acid (DNA). Post-detection, this pathway triggers the defense mechanisms ...

Study: SARS-CoV-2 spike protein–induced cell fusion activates the cGAS-STING pathway and the interferon response. Image Credit: Cinefootage Visuals / Shutterstock.com A previous study on ...

Inflammasome proteins like NLRP3 trigger ... Nucleic-acid sensing proteins like STING and cGAS alert the immune system to the presence of infected or sick cells. In some cases, drug developers ...

A study headed by researchers at the Swiss Federal Institute of Technology Lausanne (EPFL) has now shown that a molecular signaling pathway known as cGAS/STING plays a critical role in driving ...

The cGAS-STING pathway facilitates crosstalk between cancer cells and the tumor microenvironment (TME). The activation of cGAS-STING promotes the release and presentation of cancer antigens ...

5 In addition, cGAMP, which is up-regulated by cGAS activation upon cytoplasmic DNA sensing, may be an important upstream biomarker of this pathway. In conclusion, in identifying STING as a ...

inflammation, neurodegeneration and cognitive decline. EPFL professor Andrea Ablasser and her team showed that brain aging was driven by microglial activation of the cGAS/STING pathway.

The cGAS-STING signaling pathway, a key element of the innate immune response, has risen as a promising avenue to amplify this therapeutic approach. Unraveling the pathway's role in immune system ...