Immunotherapy uses the body's immune system to recognize and destroy cancer cells. One way to do this is through immune ...

"When we added the highly repetitive DNA to that really poorly immunogenic tumor type, we could see better STING activation and induce cytotoxic T cells that actually kill tumor cells," says first ...

Historically, research on STING has overwhelmingly focused on activating the pathway to recruit immune cells that attack tumors. However, inhibiting the pathway is understudied and mounting ...

Researchers have long focused on the STING (Stimulator of Interferon Genes) pathway as a way to harness the immune system's natural defenses against cancer. This pathway, which plays a key role in ...

Pancreatic ductal adenocarcinoma is the most common form of pancreatic cancer that, with a “dismal” 13% five-year survival rate, is the third leading cause of cancer deaths, the authors wrote.

5. Ishikawa H, Ma Z, Barber GN. STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity. Nature 2009;461:788-792.

Ruscetti's previous research demonstrated that two cancer drugs (MEK inhibitor trametinib and CDK4/6 inhibitor palbociclib, or T/P) can promote blood vessel development, enabling greater T cell ...