A research team led by Dr Ma identified a therapeutic small molecule, M1, which can increase the fusion and motility of mitochondria, resulting in sustained, long-distance axon regeneration.

Damage to the optic nerve can lead to irreversible blindness. A newly investigated regeneration factor could change that, UConn researchers report in the May 2024 issue of Experimental Neurology.

The second abstract, titled “HEPATOCYTE-TARGETED R-SPONDIN MIMETIC STIMULATES REGENERATION AND RESTORES COAGULATION IN A THIOACETAMIDE-INDUCED LIVER INJURY MODEL (Abstract #3346773 ...

Small molecule M1 promotes mitochondrial dynamics and sustains long-distance axon regeneration “Photoreceptors in the eyes [retina] forward visual information to neurons in the retina. To facilitate ...

More information: Agnieszka Lukomska et al, Nfe2l3 promotes neuroprotection and long-distance axon regeneration after injury in vivo, Experimental Neurology (2024). DOI: 10.1016/j.expneurol.2024. ...