"The basic idea is that you can take a tertiary alcohol with one stereochemical configuration and install nitrogen functionality, leaving it with the opposite stereochemical configuration," said ...

This transformation, in which the hydroxy group on a single carbon flips from one stereochemical configuration to the other, seems like a simple epimerization, but the reaction is quite complicated.

Synthetic phospholipids possessing natural stereochemical configuration are preferably synthesized from sn-glycero-3-phosphocholine (GPC), using acylation and enzyme catalyzed reactions. The precursor ...

The paper describes a breakthrough method to produce antisense oligonucleotide (ASO) therapeutics with high stereochemical purity as well as rational drug design to control pharmacologic ...