RNA splicing involves the removal of non-coding introns and the joining of coding exons in precursor mRNA (pre-mRNA) to produce mature messenger RNA (mRNA). Splicing changes can lead to diseases ...

Alternative splicing enables a single gene to encode multiple mRNA variants and, consequently, diversifies protein isoform products. The advent of deep sequencing technologies has revealed that 95 ...

One such nuclear body, the speckle, contains spliceosomes that are known to be involved in mRNA splicing. Disruption of speckles leads to a range of diseases and developmental disorders, yet how ...

In Huntington’s disease, the mutant huntingtin gene (HTT) mRNA is retained in the nucleus and forms insoluble clusters. A new study shows that short interfering RNA (siRNA), an oligonucleotide ...

Dr. Jun Inamo, the first author, highlights, "These findings advance our understanding of the association between alternative splicing and disease genetics.