What's the difference between mRNA and pre-mRNA? It's all about splicing of introns. See how one RNA sequence can exist in nearly 40,000 different forms. Next, the snRNPs U2 and U4/U6 appear to ...

Splicing and transcription touch base: co-transcriptional spliceosome assembly and function Pre-mRNA splicing occurs on nascent RNA, which is attached to chromatin by RNA polymerase II.

This is an important study that demonstrates that RNA intermediates arising from improper splicing are exported out of the nucleus via the canonical mRNA export machinery and the nuclear pore basket.

Although splicing has also been reported to promote mRNA export, this functional connection has been controversial. In early studies, Ryu and Mertz (18) used transfection of mammalian cells followed ...

Visualizing the machinery of mRNA splicing Date: April 8, 2008 Source: Yale University Summary: Recent research at Yale provided a glimpse of the ancient mechanism that helped diversify our ...

We confirmed the splicing patterns of the reporters by RT-PCR, and observed that exon 20 was predominantly included with the WT but almost entirely excluded with the FD type (Fig. 1 D), whereas the ...

Xue-Cheng Zhang, Walter Gassmann, Alternative Splicing and mRNA Levels of the Disease Resistance Gene RPS4 Are Induced during Defense Responses, Plant Physiology, Vol. 145, No. 4 (Dec., 2007), pp.

mRNA splicing regulation as an essential factor in osteoclast differentiation. (IMAGE) Tokyo University of Science ...

Researchers report this month that MALAT1, a long non-coding RNA that is implicated in certain cancers, regulates pre-mRNA splicing - a critical step in the earliest stage of protein production ...

Figure 1. Export of a lariat intermediate requires the mRNA export factor Mex67p. A. Schematic representation of the brA and brG export reporters. B. The brG reporter accumulates lariat intermediate, ...