We may be a step closer to a highly effective mRNA vaccine against HIV, but tests so far reveal that the approach can cause ...

Vigeneron GmbH has received IND approval from the FDA for VG-801, a novel mRNA trans-splicing gene therapy to treat Stargardt disease and other retinal dystrophies associated with mutations in the ...

The idea that speckles might be storage sites for spliceosomes triggered Guttman to look deeper into how nuclear organization might affect the splicing process. In a recent article, he showed that ...

To take advantage of cancer cells’ splicing errors, the scientists developed mRNA molecules with lab-designed introns that can only be spliced — and then translated into protein — by cells with ...

They found similar splicing changes in 52 of the 84 genes, with a similarly strong association with AD as in the ROS/MAP cohorts. What drives these splicing changes? One clue came from an in vitro ...

Alternative splicing explains how a single gene can generate more than one mRNA transcript, thus expanding the complexity of the proteome. During normal development, a large number of alternative ...

Serine/arginine-rich splicing factor 3 (SRSF3), a member of the serine/arginine (SR)-rich family of proteins, regulates both alternative splicing of pre-mRNA and export of mature mRNA from the ...

Xue-Cheng Zhang, Walter Gassmann, Alternative Splicing and mRNA Levels of the Disease Resistance Gene RPS4 Are Induced during Defense Responses, Plant Physiology, Vol. 145, No. 4 (Dec., 2007), pp.

Researchers report this month that MALAT1, a long non-coding RNA that is implicated in certain cancers, regulates pre-mRNA splicing - a critical step in the earliest stage of protein production ...

Visualizing the machinery of mRNA splicing Date: April 8, 2008 Source: Yale University Summary: Recent research at Yale provided a glimpse of the ancient mechanism that helped diversify our ...