Acylsilanes are emerging bench-stable reagents for the generation of electron-rich oxycarbenes that are difficult to access with unstable diazo compounds. Herein, we report a siloxycarbene-mediated ...

Home Articles Catalytic Asymmetric Polycyclization of Tertiary Enamides with Silyl Enol Ethers: Total Synthesis of (−)-Cephalocyclidin A ...

In 2018, Thomson group (Guo et al., 2012; Jones et al., 2014; Robinson and Thomson, 2018) reported the strategy of intra -EOC reaction using enol di -silyl ether to realize the formal synthesis of ...

Rice University chemists have discovered a one-step method to turn silicon-based silyl enol ether into nitrogen-bearing alpha-aminoketones, valuable building blocks in chemical design.

Postdoctoral researcher Zhe Zhou discovered the reaction when he mixed a silyl enol ether and a nitrogen source in a common solvent, hexafluoroisopropanol, at room temperature and found that it ...

Stereoselective Synthesis of Silyl Enol Ethers with Acylsilanes and α,β-Unsaturated Ketones Journal: Organic Letters Published: 2024-07-19 DOI: 10.1021/acs.orglett.4c01782 Affiliations: 1 Authors: 6 ...

Rice University postdoctoral researcher Zhe Zhou is lead author of a paper on the discovery of a one-step method to turn silicon-based silyl enol ether into nitrogen-bearing alpha-aminoketones ...