UCSF Benioff Children's Hospital Oakland is enrolling patients in an innovative clinical trial that seeks to cure sickle cell disease. The trial is the first in the U.S. to apply non-viral CRISPR ...

Sickle cell diseases arises from hemoglobin protein mutations. The mutation causes red blood cells to form a sickle shape rather than a round one. One study suggests that this mutation could be ...

Sickle cell anemia is the most serious form of sickle cell disease (SCD). It occurs when a person inherits an irregular hemoglobin gene from each parent. Certain groups of people are more at risk ...

In early human societies, most children with sickle cell anemia likely died by age 5. Yet the protection afforded by a single copy of the sickle cell mutation against malaria kept fueling its spread.

Having established a faster, more efficient method, the team then reprogrammed human cells that contain the mutation associated with sickle cell anemia. Embryonic stem cell-like clusters were visible ...

Sickle Cell Disease is an awful genetic disease that disproportionally affects black people. It's caused by a single-point mutation in DNA, which results in a modified hemoglobin protein, differing by ...

In 2008, the Sickle Cell Clinic at the children's hospital regularly treated 16 children. Now there are more than 80, primarily because of immigration, says Dr. Mike Leaker.

Billon says the kit can be used to diagnose a wide range of genetic mutations for blood and other disorders including sickle cell anemia and cystic fibrosis. The methods used to test it are ...