The organelles of the secretory pathway have been known for over 100 years, but explaining how they are constructed and function will remain a central problem in cell biology for some time to come.

While many of them are structurally simple, there are approximately 7,000 proteins that must be made in a cell's secretory pathway and will be either dispersed throughout the cell or secreted to ...

This important study provides solid evidence that glucosylceramide synthase (GlcT), a rate-limiting enzyme for glycosphingolipid (GSL) production, plays a role in the differentiation of intestinal ...