Both first- and second-generation antipsychotics affect the risk for TD development because of the way they work on the brain, which involves blocking dopamine receptors (D2 receptors) in the ...

Second-generation (atypical) antipsychotics also block dopamine but often target serotonin receptors, too. Long-acting injectables (LAIs) are available in both first- and second-generation forms.

The "5-HT2, D2, Me Too" Blueprint It should come as no surprise that, aside from clozapine, the effectiveness of antipsychotic therapy hasn't changed substantially in 70 years if we consider that ...