New research from the University of Missouri School of Medicine reveals more information about this vital function and how it ...

The standard textbook model of muscle contraction includes only two main players, the filaments actin and myosin, which slide past each other, causing the sarcomere—the basic unit of muscle tissue—to ...

According to the research, the protein seems to sense stress on the muscle cells and adjusts sarcomere shortening – and consequently, muscle contraction – based on how hard the heart needs to work. If ...

Numerous motor and structural proteins compose a highly ordered structure known as the sarcomere, the basic unit of muscle contraction in heart and skeletal muscles. Sarcomeric myosin heavy chain ...

To fully understand how the sarcomere functions and how it is regulated, we want to analyze it in different states e. g. during contraction“, says Raunser.

EDG-7500 is a first-in-class oral, selective, cardiac sarcomere modulator, specifically designed to slow early contraction velocity and address impaired cardiac relaxation associated with ...

Scientists have produced the first high-resolution 3D image of the sarcomere, the basic contractile unit of skeletal and heart muscle cells, by using electron cryo-tomography (cryo-ET).