Specifically, one strand of a double-stranded siRNA molecule can be incorporated into a complex called RISC. This RNA-containing complex can then inhibit transcription of an mRNA molecule that has ...

RISC can also target the viroid, forcing it to evolve and to adopt and maintain an RNA silencing-resistant structure. (From M.-B. Wang et al., Proc Natl Acad Sci, 101:3275–80, 2004.) There is growing ...

These are recognized and processed into small interfering RNAs by Dicer. The duplex siRNAs are passed to RISC (RNA-induced silencing complex), and the complex becomes activated by unwinding of the ...

Upon additional processing in the fungal cell, a single strand of the small RNA becomes part of the RNA-induced silencing complex (RISC), which then destroys an mRNA with a ... Kerry served as The ...

Double-stranded RNA; pre-miRNA: Precursor miRNA; pri-miRNA: Primary miRNA; RISC: RNA-induced silencing complex; UTR: Untranslated region. Various gene silencing technologies like siRNA ...

One strand of the mature miRNA duplex, known as the guide strand, is incorporated into the RNA-induced silencing complex (RISC). The RISC, guided by the miRNA, binds to complementary sequences in the ...

In 1998, Andrew Fire and Craig Mello published a groundbreaking study demonstrating that double-stranded RNA (dsRNA) could silence genes in the nematode Caenorhabditis elegans. This discovery laid the ...