This study, titled "Spatial organization of PI3K-PI (3,4,5)P 3 -AKT signaling by focal adhesions," was published in Molecular Cell on November 1, 2024.

More information: Wei-Wei Ren et al, MYO18B promotes lysosomal exocytosis by facilitating focal adhesion maturation, Journal of Cell Biology (2025). DOI: 10.1083/jcb.202407068 ...

Background: PDAC is an aggressive cancer. It remains refractory to checkpoint inhibition because of its significant desmoplastic and immunosuppressive tumor microenvironment (TME). Focal adhesion ...