Details of the design, synthesis, and evaluation of the antibiotic are provided in a new Science paper titled, “An antibiotic preorganized for ribosomal binding overcomes antimicrobial ...

Structural dynamics of human ribosomes in situ reconstructed by exhaustive high-resolution template matching. Molecular Cell, 2024; 84 (24): 4912 DOI: 10.1016/j.molcel.2024.11.003 ...

New antibiotics are urgently needed to address the looming global health crisis of antimicrobial resistance. Now, a study in Science reports the structure-based design of a ribosome-targeted ...

Stylized illustration of an RNA thermometer in the gene lpxP, identified in E. coli and conserved across various bacterial species. On the left, the OFF conformation. The Ribosome Binding Site ...

Through the application of protein cross-linking and high resolution mass spectrometry, we have detailed the ribosomal binding site of S1 and have observed evidence of its dynamics. Our results ...

Apart from carrying the information to encode proteins in, RNA molecules can adopt intricate 2D and 3D structures.

On the left, the OFF conformation. The Ribosome Binding Site (RBS, green) is “locked” into a stem-loop structure, hence preventing binding of the ribosome and translation of the downstream gene.

Researchers from the University of Illinois at Chicago and Harvard University have published details on the chemical synthesis and microbiological evaluation of a ribosome-binding antibiotic – ...