Among these, lentivirus-based vectors, derived from the HIV-1 retrovirus, are of growing interest in gene and cell therapy, particularly in immuno-oncology, due to their ability to infect dividing ...

Lentiviruses have the unique ability amongst retroviruses of being able to infect non-cycling cells. Vectors derived from lentiviruses have provided a huge advancement in technology and seemingly ...

Retroviruses are a sub-category of oncoviruses that include the lentiviruses. Retroviruses are negative single-stranded RNA viruses in which tRNA serves as a primer for the mRNA synthesis. The mRNA is ...

Biotech firms are engineering smarter, safer gene delivery systems to enhance the safety and efficacy of genetic medicines.

They can employ either recombinant viruses, such as adenovirus, adeno-associated virus (AAV), retrovirus, or lentivirus, or non-viral platforms, such as lipid nanoparticles, to transport the chosen ...

For retroviruses in general, viral nucleic acids seem to access the nucleus during mitosis. In contrast, lentiviruses such as human immunodeficiency virus (HIV) do not depend on host cell mitosis ...

Current projects in the laboratory focus on retroviruses, specifically the lentiviruses of humans and their primate relatives (the human and simian immunodeficiency viruses – HIV and SIV). Among other ...

To achieve this, Gag binds to a region of the genomic RNA that, depending on the retrovirus, is about 100 to 300 nucleotides long and contains encapsidation signals. This region is therefore ...