A study links the loss of DNA methylation across the genome—as is common in cancer—to the disruption of the 3-D compartments that organize the genome and to the timing of DNA replication. Cell lines ...

Humans and baker's yeast have more in common than meets the eye, including an important mechanism that helps ensure DNA is copied correctly, reports a pair of studies. The findings visualize for ...

DNA replication is a fundamental process for a cell to ensure that an accurate copy of its genetic material is transmitted to daughter cells at each cell division. Challenges to DNA replication ...

The findings visualize for the first time a molecular complex - called CTF18-RFC in humans and Ctf18-RFC in yeast - that loads a "clamp" onto DNA to keep parts of the replication machinery from ...

DNA Mutation and Repair DNA mutations are changes in the nucleotide sequence of the DNA molecule. Mutations can occur spontaneously due to errors during DNA replication or as a result of exposure to ...

Researchers have found that the “mother” of all stem cells, known as totipotent stem cells, have a much slower rate of DNA replication, which helps improve their efficiency at differentiating ...

When DNA is unwound at the O H, the mitochondrial single-stranded DNA-binding protein (mtSSB) coats the displaced strand to prevent POLMRT-mediated initiation at random. The replication fork ...

Technology DNA nanobots can exponentially self-replicate Tiny machines made from strands of DNA can build copies of themselves, leading to exponential replication. Similar devices could one day be ...

An effective sweeper closes DNA replication cycling ATAD5-RLC unloads PCNA to cut off genetic mutations Date: June 3, 2019 Source: Institute for Basic Science Summary: Scientists reported a novel ...