Introduction Physiology of the Renin-Angiotensin-Aldosterone System and Its Pathophysiologic Role in Some Forms of Hypertension Renin in the Selection of Antihypertensive Drug Therapy Renin as a ...

Renin plays a clinically significant role in both the regulation of arterial blood pressure and within the renin–angiotensin system in cardiovascular diseases.

Canada: A study published in Circulation found that subclinical primary aldosteronism significantly increases the risk of ...

The renin–angiotensin–aldosterone system (RAAS) is well established as a therapeutic target in patients with heart failure. Professors Lang and Struthers discuss new indications for existing ...

Two studies of the novel oral renin inhibitor suggest aliskiren provides continuous BP control over 24 hours with one dose and that it has efficacy similar and potentially additive to ...

Renin catalytically cleaves these circulating angiotensinogen and forms angiotensin I. Angiotensin-converting enzymes then convert angiotensin I to its physiologically active form, angiotensin II.

These patients are often prescribed renin–angiotensin–aldosterone system (RAAS) inhibitors, including angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers (ARBs). This ...

The renin cells then trigger a buildup of another cell type, smooth muscle cells, that cause the vessels to thicken and stiffen. The result: Blood can't flow through the kidney as it should.

Another pharmacologic approach to reducing the risk of diabetes and cardiovascular disease is inhibition of the renin–angiotensin system. Some studies have shown that angiotensin-converting ...