While he defended the Meta CEO from criticism for attending Trump's 2025 inauguration, Hoffman has previously warned that social media companies have an obligation to uphold fact-checking standards.

Hoffman praised design choices like Inflection AI's Pi assistant, which explicitly tells users, "I'm your companion," and encourages people to spend time with actual human friends.

Reid Hoffman praises Shopify CEO Tobi Lütke’s recent company memo as a model for workplace integration of AI, spotlighting artificial intelligence’s increasing role in leadership and management.