Each antibody molecule possesses distinct variable and constant regions. The variable region confers an antibody's antigen-binding specificity. This region contains two fragment antigen binding ...

An electrochemical sensor designed to address a global health issue that particularly impacts people in the Middle East and North Africa (MENA) has been created by a multidisciplinary team at KAUST.

The technique, which focuses on modeling the hypervariable regions of antibodies, also holds potential for analyzing entire antibody repertoires from individual people. This could be useful for ...

The researchers say antibodies in this class are particularly promising because they bind to regions of the malaria parasite not included in current malaria vaccines, providing a potential new ...

However, they usually provide test results rapidly, are relatively cheap, and can be more amenable to point-of-care use, which could make them more suitable for testing in the community and in remote ...

The models identified two key structural features on the antibodies. One was loop regions, highly variable regions on the antibody that are most responsible for their function and that recognize ...

These negatively charged regions mediate strong binding of the antibodies to the positively charged arginine and lysine residues on PF4. 5 Panel A shows proteomic profiling of serum antibodies ...

The researchers say antibodies in this class are particularly promising because they bind to regions of the malaria parasite not included in current malaria vaccines, providing a potential new ...

biodegradable polymer at the hinge and near hinge regions of the therapeutic antibody trastuzumab effectively facilitated the brain delivery of this human monoclonal IgG1 antibody. Trastuzumab is used ...

A new study shows that a series of vaccines can coax the immune system to produce powerful antibodies capable of blocking a ...

When scientists engineer a better way to fight the flu, they often begin with nature’s own defenses. That’s what a new study from researchers at The Ohio State University set out to do. Their goal was ...

To overcome that limitation, MIT researchers have developed a computational technique that allows large language models to ...