“These RNA-binding small molecules selectively inhibit the two steps of splicing by adopting distinctive poses at different stages of catalysis, and by preventing crucial active site ...

Summary RNA splicing is a post-transcriptional modification process that occurs in eukaryotic cells. When a gene is transcribed, the initial RNA product is called pre-mRNA, which contains both coding ...

A $1.6million grant from the National Institute of Health (MD, USA) has been awarded to study the underlying biochemistry and crystallography of RNA splicing using bacteria from hot springs. Roughly ...

Splicing of precursor mRNAs generally occurs co-transcriptionally, thus promoting the correct sequential splicing of exons as they emerge from RNA polymerase II. However, for alternatively spliced ...

RNA splicing is a major underlying factor that links mutations to complex traits and diseases, according to an exhaustive analysis of gene expression in whole genome and cell line data ...

For those not familiar with RNA science, there are a couple of key steps. Before proteins can be synthesized, our DNA must be transcribed into RNA.

Consequently, researchers can correlate splicing errors to diseases and determine their specificity. Currently, there are 370 known genetic disorders caused by RNA splicing errors.

Building proteins RNA splicing, a process discovered in the late 1970s, allows cells to precisely control the content of the mRNA transcripts that carry the instructions for building proteins.

The company used whole exome and RNA sequencing to analyze 10,000 patient samples across 33 tumor types. The analysis looked at more than 400 splicing factors, turning up 199 genes with putative ...

By designing gRNAs to target these specific sites, CRISPR-Cas9 can be utilized to introduce precise modifications and manipulate splicing. Following CRISPR-Cas9 treatment, RNA-Seq can be performed to ...

Researchers report this month that MALAT1, a long non-coding RNA that is implicated in certain cancers, regulates pre-mRNA splicing -- a critical step in the earliest stage of protein production.