“These RNA-binding small molecules selectively inhibit the two steps of splicing by adopting distinctive poses at different stages of catalysis, and by preventing crucial active site ...

HNF1A mutations are found to dysregulate RNA splicing in pancreatic cells, thereby contributing to the onset of diabetes.

A group of Australian scientists has uncovered a new way to fight some of the toughest cancers by targeting an overlooked ...

Building proteins RNA splicing, a process discovered in the late 1970s, allows cells to precisely control the content of the mRNA transcripts that carry the instructions for building proteins.

This study reports important negative results by showing that genetic removal of the RNA-binding protein PTBP1 in astrocytes is not sufficient to induce their conversion into neurons, challenging ...

RNA splicing is a cellular process that is critical for gene expression. After genes are copied from DNA into messenger RNA, portions of the RNA that don't code for proteins, called introns, are ...

RNA splicing is a heavy lift, but our cells make it look easy. New research from CSHL Professor Adrian Krainer may help explain how. Krainer’s latest study reveals a previously unseen link ...

Now, his team has discovered that two important regulator proteins work together to keep the splicing process on track. One of those regulators, a protein called SRSF1, has been a focus of Krainer ...