BigRNA is the first foundation model for RNA that has been shown to be effective for a range of drug discovery tasks, including predicting the effects of patient variants on RNA processing mechanisms, ...

Researchers at the University of Toronto have harnessed a bacterial immune defence system, known as CRISPR, to efficiently and precisely control the process of RNA splicing. The technology opens the ...

Australian researchers have discovered a promising new strategy to suppress the growth of aggressive and hard-to-treat ...

The modulation of RNA splicing by small molecules has emerged as a promising strategy for treating pathogenic infections, human genetic diseases, and cancer; however, the principles by which ...

Building proteins RNA splicing, a process discovered in the late 1970s, allows cells to precisely control the content of the mRNA transcripts that carry the instructions for building proteins.

They found that deleting the new factor — instead of the mutant — shifts abnormal RNA splicing patterns back toward normal. “It’s not common to find a new splicing factor, let alone one that does ...

Building proteins RNA splicing, a process discovered in the late 1970s, allows cells to precisely control the content of the mRNA transcripts that carry the instructions for building proteins.

“For example, we could use this model to observe what types of proteins will form if the RNA-splicing process were to remove only two parts of a DNA sequence instead of three,” Luthey-Schulten said.

In a new study, researchers demonstrate that deregulation of a protein called RBFOX2, involved in RNA splicing, contributes to the progression and metastasis of pancreatic cancer.

To test the new model, the team performed simulations of a process called RNA splicing, which is one of the most complex cellular processes and a hallmark of human cellular biology, the researchers ...