Technology Review Published: February 2000 RNA interference: genetic wand and genetic watchdog Julia M. Bosher & Michel Labouesse Nature Cell Biology 2, E31–E36 (2000) Cite this article ...

Consequently, the RNA transcripts generated by pSUPER and pRETRO-SUPER self-fold into a stem–loop structure resembling a hairpin, and were therefore called short hairpin RNAs (shRNAs).