The new study, published in the journal Nucleic Acids Research, focuses on critical snippets of RNA in the tiny, transparent roundworm Caenorhabditis elegans (C. elegans).

Journal: Proceedings of the National Academy of Sciences of the United States of America Published: 2024-12-03 DOI: 10.1073/pnas.2416982121 Affiliations: 3 Authors: 5 ...

C. elegans & worm SAGE, TEC-RED, RNAseq, TSS: protein-coding genes RNA Pol II Accumulates at Promoters of Growth Genes During Developmental Arrest ( Baugh et al., Science, 2009) Comparison of diverse ...

The discovery of RNAi dates back to the 1990s when researchers observed unexpected gene silencing in plants and fungi. In 1998, Andrew Fire and Craig Mello published a groundbreaking study ...

Strikingly, in certain mutants of small RNA pathway factors (e.g., eri-1, ergo-1, or drh-3), researchers found that NRDE-3 accumulates in the peri-centrosomal foci in embryos.

They then showed that humans and flies also express this 21-nucleotide RNA and that in flies and zebrafish these tiny RNA genes are turned on only at late stages of development, just as in C. elegans.

Andrew Z. Fire and Craig C. Mello, who were awarded the Nobel Prize in 2006, described RNA interference, in which specific mRNA molecules are inactivated by the addition of double-stranded RNA ...

A staple in laboratories worldwide, C. elegans is “an experimental dream,” said one scientist. Caenorhabditis elegans, one millimeter long, has just 959 cells.