Then, α-ketoglutarate enters the tricarboxylic acid (TCA) cycle, where it undergoes reductive carboxylation to generate citrate and is transported to the cytoplasm by SLC25A1 (Yoo et al., 2020). As a ...

The researchers also observed that 6-PPDQ exposure decreased acetyl CoA and pyruvate contents, which are important for the control of citric acid cycle. Acetyl CoA generated from pyruvate is a key ...

Recent studies have revealed the mechanism by which NO blocks the activity of mitochondrial TCA cycle enzymes, including pyruvate dehydrogenase (PDH), which impacts acetyl-CoA production (27 – 29).

The first committed step in fatty acid synthesis is mediated by acetyl-CoA carboxylase (ACCase), a biotin-dependent enzyme that carboxylates acetyl-CoA to produce malonyl-CoA. ACCase can be feedback ...

An allosteric inhibitor of acetyl-CoA carboxylase reveals a metabolic liability of non-small-cell lung cancer and slows tumor growth alone and in combination with chemotherapy in mouse models ...

Carl Andre, Richard P. Haslam, John Shanklin, Feedback regulation of plastidic acetyl-CoA carboxylase by 18:1-acyl carrier protein in Brassica napus, Proceedings of the National Academy of Sciences of ...

Ethylene plays its essential roles in plant development, growth, and defense responses by controlling the transcriptional reprograming, in which EIN2-C-directed regulation of histone acetylation is ...

Ethylene plays its essential roles in plant development, growth, and defense responses by controlling the transcriptional reprograming, in which EIN2-C-directed regulation of histone acetylation is ...