PFORs oxidize pyruvate to generate acetyl-CoA and carbon dioxide or, alternatively, catalyze the synthesis of pyruvate from acetyl-CoA and carbon dioxide (Fig. 1B). The oxidation of pyruvate by PFOR ...

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The study found that among the genes encoding components of the pyruvate dehydrogenase complex, which controls acetyl CoA synthesis, only dlat-1 and dld-1 expressions were decreased by 6-PPDQ.

As an important metabolite, acetyl-CoA usually originates from glucose, fatty acid, and amino acid catabolism. In the glycolysis process, glucose is transformed into cytosolic pyruvate, which is ...

Reaction scheme showing the proposed inhibitory mechanism of pyruvate carboxylating activity by l-aspartate in the presence of acetyl-CoA, where k 0 and k cat are catalytic rate constants for the ...

The therapeutic effects of pyruvate were comparable to those of 5-aminosalicylic acid (5-ASA), a standard UC treatment, but with the added benefit of being an oral small molecule. These findings not ...

Ethylene plays its essential roles in plant development, growth, and defense responses by controlling the transcriptional reprograming, in which EIN2-C-directed regulation of histone acetylation is ...