Objectives To study the molecular pathogenesis of PAPA (pyogenic arthritis, pyoderma gangrenosum and acne) syndrome, a debilitating hereditary autoinflammatory disease caused by dominant mutation in ...

Pyogenic granulomas are benign, or noncancerous, red lumps with moist surfaces that appear on your skin. They bleed easily due to having many blood vessels and can appear after you’ve had an ...

The main pathophysiological mechanism associated with PG is the activation of the inflammasome and the overproduction of IL-1, and occasionally IL-17, an observation also described in FMF, explaining ...