DEWS levels 2 to 4 DES patients have symptoms and signs. The core signs are corneal staining (punctate epithelial erosion and punctate epithelial keratitis), inflammation and hyperosmolarity.

Superficial punctate keratitis is the most common corneal complication of VKC [26] and may also be seen in AKC, although never in SAC or PAC. Punctate epithelial keratitis may coalesce to form an ...

Results of the Epithelial Keratitis Trial performed by the Herpetic Eye Disease Study (HEDS) Group [102] showed that adding oral acyclovir to topical antiviral medications when treating infectious ...