New research uncovers new insights into preventing chronic inflammation caused by aging-related zombie-like cells. In humans ...

Munoz, and Fred Bunz from the Sidney Kimmel Comprehensive Cancer Center and Johns Hopkins University School of Medicine studied the tumor-suppressing protein p53, which plays a key role in ...

Although there are tumor suppressor genes in normal cells to prevent cancer, gene mutations can cause a normal cell to become a cancerous one. Among those genes, TP53 (encoding the p53 protein) has ...

New findings show that the mitochondria powering our cells also control the ability of a DNA repair protein to suppress the senescence-associated secretory phenotype (SASP), which causes zombie-like ...

Munoz, and Fred Bunz from the Sidney Kimmel Comprehensive Cancer Center and Johns Hopkins University School of Medicine studied the tumor-suppressing protein p53, which plays a key role in ...

New research illustrates how a DNA repair protein suppresses senescent cells, reducing age-associated chronic inflammation.

One such mechanism involves a protein called p53. Often dubbed the "guardian of the genome," this protein plays a pivotal role in ensuring that your cells grow, divide and die in an orderly fashion.

p53 enhances DNA repair and suppresses cytoplasmic chromatin fragments and inflammation in senescent cells - ...

Shelby is an Assistant Editor for The Scientist. She earned her PhD from West Virginia University in immunology and microbiology and completed an AAAS Mass Media fellowship. View Full Profile. Learn ...

PNC-27 is a synthetic peptide composed of 32 amino acids. It is engineered to contain the MDM-2 binding domain of the tumor ...