Alain Rahier, Marc Bergdoll, Geneviève Génot, Florence Bouvier, Bilal Camara, Homology Modeling and Site-Directed Mutagenesis Reveal Catalytic Key Amino Acids of 3β-Hydroxysteroid-Dehydrogenase/C4- ...

The hybrid approach taken by the researchers combined protein-protein docking, homology modeling, and the available experimental data. They first validated the modeled parts of the S protein and ...

Protein homology modeling using wild-type and mutant predicted C2H2 ZnF domain 3D structure showed that mutation of glycine to arginine results in the formation of a new hydrogen bond interaction ...

The three-dimensional model of a-subunit of Biphenyl dioxygenase (BphA) from Comamonas testosteroni B-356 has been constructed. The kinetic parameters of biphenyl compounds were well matched with the ...

The model provides a coherent and satisfying framework for better understanding AD pathophysiology. Moreover, the DR6-NAPP interaction offers a tempting target for novel pharmacological intervention.