With less follicle recruitment, the ovarian reserve seems to be prolonged. Previous research in mice has shown that rapamycin recruits fewer follicles, which may preserve ovarian reserve.

Older female mice who were given a diet containing rapamycin had an increase in their pool of primordial follicles — the ovarian reserve. Moreover, these mice also had successful litters later ...

This study entitled "The neonatal ketone body is important for primordial follicle pool formation and regulates ovarian aging in mice" is published online in Life Metabolism on August 2022.

This study entitled “The neonatal ketone body is important for primordial follicle pool formation and regulates ovarian ageing in mice” is published online in Life Metabolism on August 2022.

Patterns of primordial follicle loss in different women explain the ‘unpredictable timing’ of menopause and the earlier menopausal transition,” Johnson said.

“They’re reserve.” The body produces estrogen when a primordial follicle begins to mature an egg, and then it produces progesterone after ovulation occurs.

In women who received rapamycin, only 15 follicles were recruited per menstrual cycle – compared to 50 in women at similar age. With less follicle recruitment, the ovarian reserve seems to be ...