Researchers at Rockefeller showed that this process is mediated by two enzymes: telomerase and the CST–Polα/primase complex. Having determined how telomerase is recruited, scientists were left ...

In H1, the company hopes to initiate a first-in-human (FIH) trial of its candidate ABI-5366, a helicase-primase inhibitor targeting patients with HSV2, specifically recurrent genital herpes.

How would you identify the protein that serves as a connector between DNA helicase and pol-a/primase? A simple yet often effective approach is to find proteins that directly bind to both enzymes.

Primase, eine an der DNA-Synthese (Replikation) beteiligte spezifische RNA-Polymerase, die die Synthese eines kurzen RNA-Abschnitts katalysiert, der komplementär zu einem der DNA-Matrizenstränge ist.