Assembly Biosciences, Inc.'s ABI-5366 showed strong interim phase 1b results in HSV-2 recurrent genital herpes patients.

Assembly Biosciences ( NASDAQ: ASMB) reported promising results from an early stage study of its experimental candidate, ...

Typically, primase initiates synthesis, extends the primer to a defined length of between 9 and 16 nt, and then disengages to allow association of a DNA polymerase with the primer’s 3′-OH end. In the ...

The VACV D5 protein has a primase domain in the N-terminal region and an NTPase/helicase domain in the C-terminal region, an arrangement that is also found in some other archaeoeukaryotic primases (16 ...

The herpes simplex virus (HSV) causes cold sores and genital lesions and with the exception of acyclovir (an inhibitor of the viral DNA polymerase), there are currently no drug treatments available.

The primase and DNA polymerase activity are located in the N‐terminal half of the protein, which does not show homology to any known DNA polymerase or primase. ORF904 constitutes a new type of ...

In this study, we used an affinity purification approach to isolate RPA‐containing complex and identified a novel protein CCDC111, which we refer to as hPrimpol1 (human primase‐polymerase 1).

POT1 recruits and regulates CST-Polα/primase at human telomeres. Cell, 2024; DOI: 10.1016/j.cell.2024.05.002 ...

In the interests of transparency, eLife publishes the most substantive revision requests and the accompanying author responses. Thank you for submitting your article "A novel DNA primase-helicase pair ...

CST–Polα/primase, the enzyme that solves the newly discovered end-replication problem. Credit: Sarah Cai The Lagging-Strand Problem As descriptions of biological processes go, this model looked ...