Researchers from Cerevel Therapeutics LLC presented data from a study that aimed to evaluate preclinical antipsychotic properties of M4 agonism while minimizing off-target side effects using novel ...

The known role of brain-derived neurotrophic factor (BDNF) in the development and maintenance of interneurons, together with our previous results showing improved PV interneuronal function and ...

AC-3933 potently inhibited [3H]-flumazenil binding to rat whole brain membrane with a Ki value of 5.15 ± 0.39 nM and a γ-aminobutyric acid (GABA) ratio of 0.84 ± 0.03. AC-3933 exhibited almost no ...

7-hydroxymitragynine (7OH) is a naturally occurring alkaloid found in the kratom plant (Mitragyna speciosa). As a partial agonist of the mu-opioid receptor, 7OH produces a range of effects ...

Researchers from Roche Holding AG disclosed the discovery and preclinical evaluation data for RG-7774 (vicasinabin), a novel cannabinoid CB2 receptor (CB2R) agonist being developed for the treatment ...