That’s because of the partial antagonistic activity that it has. You have to be very careful as to how you get people on this drug.

Buprenorphine, a partial agonist, is also used to treat opioid use disorder. It’s typically used alongside the opioid antagonist naloxone to help manage mild to moderate withdrawal symptoms.

The orexin deficit is believed to be the root cause of narcolepsy Mazindol ER is the most advanced Orexin-2 partial receptor agonist in development for the treatment of narcolepsy and other rare ...

The partial D 2 -agonist activity of aripiprazole is combined with partial agonist activity at serotonin 5-HT 1A receptors and antagonism at 5-HT 2A receptors, and its affinity for other receptors ...

“There’s great interest and need for drugs with selective D1/D5 dopamine receptor partial agonist activity as a path to minimize the common side effects of current dopamine agonist drugs ...

STK-012 attempts to overcome that by acting as a partial agonist, selectively stimulating antigen-activated T cells associated with anti-tumour activity, whilst avoiding stimulation of toxicity ...

MENLO PARK, Calif.--(BUSINESS WIRE)--Synthekine Inc., an engineered cytokine therapeutics company, today presented new data from preclinical studies of STK-026, its biased IL-12 partial agonist ...

The known role of brain-derived neurotrophic factor (BDNF) in the development and maintenance of interneurons, together with our previous results showing improved PV interneuronal function and ...

STK-012, an IL-2 partial agonist, is designed to selectively stimulate T cells that recognize tumor antigens and has demonstrated single-agent activity in preclinical tumor models.

Two identical studies measuring differing concentrations of mazindol ER confirmed significant OX2R partial agonist activity at 30μM or higher.