PTX3 is rapidly released from neutrophils on stimulation with microorganisms or TLR agonists, 23 and recombinant PTX3 binds to late apoptotic cells. 20, 21, 22 The detection of membrane PTX3 on ...

In PTX3 WT mice, MHV-1 induced PTX3 expression in the lung and serum in a time-dependent manner. MHV-1 infection led to acute lung injury with greater severity in PTX3-deficient mice than that in ...

Methods and Results— PTX3 expression increases in the vascular wall of apolipoprotein E–knockout mice from 3 up to 18 months of age. Double-knockout mice lacking PTX3 and apolipoprotein E were fed an ...

The long pentraxin 3 (PTX3) exerts a variety of regulatory functions in acute and chronic tissue inflammation. In particular, PTX3 acts as an opsonin for a variety of pathogens and endogenous ...

Moreover, PTX3 participates in the regulation of inflammation as well as in extracellular matrix formation promoting fibrocyte differentiation (Pilling et al., 2015). However, in acute myocardial ...

PTX3 contains nine cysteine residues, of which five are involved in intermonomer oligomerization (Fig. 1 A) (7). Within the higher-order PTX3 oligomer, there are therefore multiple disulphide bonds ...

PTX3 is a long pentraxin that was recently found to be increased in patients with acute myocardial infarction. Because tissue factor (TF), the in vivo trigger of blood coagulation, plays a dominant ...

Background: Pentraxin-3 (PTX) levels are elevated in the serum and synovium of rheumatoid arthritis (RA) patients, and high PTX3 levels have been linked to increased disease activity and radiographic ...

China: In a new study conducted by Guobin Wang and the team, it was found that individuals with sepsis who did not survive had much greater levels of Pentraxin-3 (PTX3) than patients who did.

About 41 percent of the SLE patients without renal involvement had increased levels of anti-PTX3 auto-antibodies, compared to 20 percent of those with lupus nephritis. Interestingly, these ...