No one really understands why activation of the tumor suppressor p53 sometimes leads to cell-cycle arrest and sometimes induces an apoptotic program. It has been proposed that post-translational ...

Figure 8: Regulation of ALDH3A1 and NECTIN4 by p53. Researchers Jessica J. Miciak, Lucy Petrova, Rhythm Sajwan, Aditya Pandya, Mikayla Deckard, Andrew J. Munoz, and Fred Bunz from the Sidney ...

"Our work will have a huge impact on mRNA and RNAi-based therapies and drug ... we can restore tumor suppressor gene expressions such as PTEN, P53, or tumor antigens for immunotherapy while ...

D.P. Lane, S. Benchimol, "p53: Oncogene or anti-oncogene?" Genes & Development, 4:1-8, 1990. David Lane (Cancer Research Campaign Laboratories, University of Dundee, Scotland): "Cancer is a multistep ...

These treatments may utilize techniques such as mRNA introduction ... we can restore tumor suppressor gene expressions such as PTEN, P53, or tumor antigens for immunotherapy while simultaneously ...