The scientists fused the target binding sequence to a reporter with strong expression to assess if p53 could repress its transcription. When the results didn’t show any reduction in gene expression, ...
New research uncovers new insights into preventing chronic inflammation caused by aging-related zombie-like cells. In humans ...
Figure 8: Regulation of ALDH3A1 and NECTIN4 by p53. Researchers Jessica J. Miciak, Lucy Petrova, Rhythm Sajwan, Aditya Pandya, Mikayla Deckard, Andrew J. Munoz, and Fred Bunz from the Sidney ...
No one really understands why activation of the tumor suppressor p53 sometimes leads to cell-cycle arrest and sometimes induces an apoptotic program. It has been proposed that post-translational ...
A new research paper was published in Oncotarget, Volume 16, on February 18, 2025, titled "Robust p53 phenotypes and prospective downstream targets in telomerase-immortalized human cells.
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DNA Repair Protein Suppresses "Zombie" Cells, Reducing Age-Related InflammationNew research illustrates how a DNA repair protein suppresses senescent cells, reducing age-associated chronic inflammation.
p53 enhances DNA repair and suppresses cytoplasmic chromatin fragments and inflammation in senescent cells - ...
Activation of p53 was tested by blotting for p53 expression and activation. Caspase 8 activation and apoptosis was tested by blotting for Caspase 8 expression and activation of downstream targets.
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