The scientists fused the target binding sequence to a reporter with strong expression to assess if p53 could repress its transcription. When the results didn’t show any reduction in gene expression, ...

Nevertheless, how p53 modulates TIME is still elusive ... In addition, IL-34 exposure resulted in noteworthy increased CD36 expression, causing the TAMs to polarize toward the pro-tumoral phenotype.

New research uncovers new insights into preventing chronic inflammation caused by aging-related zombie-like cells. In humans ...

New research illustrates how a DNA repair protein suppresses senescent cells, reducing age-associated chronic inflammation.

Scientists at Sanford Burnham Prebys and collaborators across the country published findings March 5, 2025, in Nature ...

No one really understands why activation of the tumor suppressor p53 sometimes leads to cell-cycle arrest and sometimes induces an apoptotic program. It has been proposed that post-translational ...

p53 enhances DNA repair and suppresses cytoplasmic chromatin fragments and inflammation in senescent cells - ...

Activation of p53 was tested by blotting for p53 expression and activation. Caspase 8 activation and apoptosis was tested by blotting for Caspase 8 expression and activation of downstream targets.