New research uncovers new insights into preventing chronic inflammation caused by aging-related zombie-like cells. In humans ...

One group showed that p53 controlled the progression of the cell cycle, but it wasn’t clear how. 24 Guillermina Lozano entered the p53 field as a postdoctoral fellow in Levine’s lab in 1985 and ...

the mechanisms by which p53 mediates cell-cycle arrest or apoptosis still remain unclear. There must be some way to specify which target genes of p53 are to be selected. The different serine ...

Among the p53 target genes are WAF1, an inhibitor of cyclin-dependent protein kinases (CDKs) that, among other activities, causes cell-cycle arrest, and BAX, which promotes apoptotic cell death.

A team led by Prof. Wuran Wei from West China Hospital of Sichuan University and Dr. Dechao Feng from the Division of Surgery and Interventional Science at University College London has systematically ...

This was accompanied by downregulation of key cell cycle proteins such as CDK2, Cyclin A2, CDK4/6, and Cyclin D1/E1 complexes. Additionally, ferulic acid upregulated tumor suppressor proteins p53 ...

Ubiquitin-specific protease 7 (USP7) is involved in DNA repair and cell cycle progression and, due to its control over the ubiquitination of key proteins, may impact oncogenes like MDM2 and c-Myc, as ...

Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-related mortality worldwide. Current treatment modalities are few or ...

HIV-1 Vif induces a unique and prolonged pseudo-metaphase arrest by disrupting phosphatase feedback regulation at the kinetochore.