New research illustrates how a DNA repair protein suppresses senescent cells, reducing age-associated chronic inflammation.

When p53 malfunctions, the result is often cancer. Learning about how p53 works has not only deepened how scientists understand cancer, but also provided promising avenues for new treatments.

New research uncovers new insights into preventing chronic inflammation caused by aging-related zombie-like cells. In humans ...

Although there are tumor suppressor genes in normal cells to prevent cancer, gene mutations can cause a normal cell to become ...

Munoz, and Fred Bunz from the Sidney Kimmel Comprehensive Cancer Center and Johns Hopkins University School of Medicine studied the tumor-suppressing protein p53, which plays a key role in ...

Munoz, and Fred Bunz from the Sidney Kimmel Comprehensive Cancer Center and Johns Hopkins University School of Medicine studied the tumor-suppressing protein p53, which plays a key role in ...

New findings show that the mitochondria powering our cells also control the ability of a DNA repair protein to suppress the senescence-associated secretory phenotype (SASP), which causes zombie-like ...

Scientists dive into the genomes of whales, elephants, and other animal giants looking for new weapons in the fight against ...

Evasion of apoptosis is a key hallmark of cancer – inactivation of p53 is a central mechanism by which tumours escape the body’s control mechanisms and promote tumour growth and proliferation.

p53 enhances DNA repair and suppresses cytoplasmic chromatin fragments and inflammation in senescent cells - ...