Although COP1 was recently discovered to exhibit E3 ubiquitin ligase activity toward p53 (Dornan et al, 2004), the existence of the CSN–COP1–p53 pathway and its upstream regulator in mammalian cells ...

COP1 is a RING finger-containing protein that targets p53 for degradation to the proteasome and is necessary for p53 turnover in normal and cancer cells. However, the association between COP1 and ...

Tumour suppressor p53 levels in the cell are tightly regulated by controlled degradation through ubiquitin ligases including Mdm2, COP1, Pirh2, and ARF‐BP1. The ubiquitination process is reversible ...

It binds to both wild-type and mutant p53 protein, inhibiting constitutional morphogenic protein 1 (Cop1)-mediated ubiquitination and proteasomal degradation of p53. This results in increased levels ...

Trim24 joins several other ubiquitin ligases (Table 1) that promote ubiquitin-mediated degradation of p53 including Mdm2, Pirh2, Cop1, ARF-BP1, TOPORS, Synoviolin, CARP1, and CARP2 (1, 2, 10 – 15).

Curtis C. Harris, p53 Tumor Suppressor Gene: At the Crossroads of Molecular Carcinogenesis, Molecular Epidemiology, and Cancer Risk Assessment, Environmental Health Perspectives, Vol. 104, Supplement ...

News & Views Published: June 2000 COP1 patrols the night beat Raymond J. Deshaies & Elliot Meyerowitz Nature Cell Biology 2, E102–E104 (2000) Cite this article ...

In resting cells, p53 protein levels are low because of the activity of several E3 ubiquitin ligases such as Mdm2, PirH2, and COP1 (3). In the presence of DNA lesions, p53 is released from this ...

Introduction The function of p53 is universally disrupted in human cancers, either by a mutation in the p53 gene locus or aberration in p53 regulation (Levine, 2020). Approximately 50% of all human ...

p53 and RB are at the heart of the two main tumour-suppressor pathways that control cellular responses to potentially oncogenic stimuli. Each pathway consists of several upstream regulators and ...