Immunohistochemical analysis of p53, Bcl-2, and Bax expression was performed with a labeled streptavidin-biotin system by means of an automated immunostainer (Ventana Medical Systems, Tucson, AZ).

Statistical analysis showed a positive correlation between p53 and PCNA expression in CIN I (r =0.378, P=0.016). A similar correlation was found between p53 and Bcl-2 expression in CIN II/III (r ...

The aim of this study was to evaluate the prognostic value of the expression of Ki-67, TS, p53, bcl-2, EGFR, MLH1 and MSH2 in specimens of CRC. Methods: The bio-markers were immunohistochemically ...

The intervention involves the investigational drug ABBV-453, a BCL-2 inhibitor, administered orally. It is tested alone or in combination with daratumumab, dexamethasone, and pomalidomide, aiming to ...

Metabolic dysfunction-associated steatotic liver disease (MASLD, formerly NAFLD) and aging are locked in a vicious circle: ...

European Journal of Cancer Prevention, Vol. 15, No. 3 (JUNE 2006), pp. 258-265 (8 pages) Aims: To analyse the extent, relationship and clinical significance of apoptosis and cell proliferation in ...

Ascentage Pharma (NASDAQ: AAPG; HKEX: 6855) is a global biopharmaceutical company dedicated to addressing unmet medical needs in cancers. The company has built a rich pipeline of innovative drug ...

"Our scenario consolidates a lot of evidence from our group and other researchers to explain how p53, Bcl-xL, and PUMA work together to trigger apoptosis," said Douglas Green, Ph.D., chair of the ...

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