These findings suggest that TEFM is crucial for the proper regulation of mtDNA replication, particularly at the origin of replication of the heavy strand. In addition, the deletion of TEFM resulted in ...

The DNA packed inside every human cell contains instructions for life, written in billions of letters of genetic code. Every ...

Mitochondrial transcription elongation factor maintains the balance between transcription and replication of mitochondrial DNA offering insights into potential treatments for mitochondrial disease ...

Unwinding of a eukaryotic origin of replication visualized by cryo-EM Journal: Nature Structural & Molecular Biology Published: 2024-05-17 DOI: 10.1038/s41594-024-01280-z Affiliations: 5 Authors: 11 ...