Human Organic cation transporter 1 (hOCT1), encoded by the SLC22A1 gene, is the transporter responsible for its uptake into target cells. As SLC22A1 is a highly polymorphic gene, the aim of this study ...

Rationale: β1ARs (β1-adrenoceptors) exist at intracellular membranes and OCT3 (organic cation transporter 3) mediates norepinephrine entry into cardiomyocytes. However, the functional role of ...

Organic cation transporters (OCT) play an important role in mediating cellular uptake of several pharmaceuticals, such as the antidiabetic drug metformin and the platinum-derived chemotherapeutics.

The organic cation transporters OCT1 and OCT2 (SLC22A1 and -A2) were first identified as polyspecific carriers capable of transporting a broad range of organic cations (1−3) and early data already ...

In this article, we focus on probe drugs lacking significant metabolism to highlight mechanisms of interactions of selected intestinal, hepatic and renal drug transporters (e.g., organic anion ...

More information: Ratna Chaturvedi et al. Drosophila Vision Depends on Carcinine Uptake by an Organic Cation Transporter, Cell Reports (2016). DOI: 10.1016/j.celrep.2016.02.009 ...

Here we demonstrate that expression of the organic cation transporter type 3 (OCT3, SLC22A3), which also transports 5-HT, is upregulated in the brains of mice with constitutively reduced 5-HTT ...