NATIONAL HARBOR, MD — Opioid-induced hyperalgesia is among the most pressing concerns in the national discussion of opioid addiction, underscored by the US Food and Drug Administration's (FDA ...

Anapindi KDB, Yang N, Romanova EV, et al. PACAP and other neuropeptides link chronic migraine and opioid-induced hyperalgesia mouse models. Mol Cell Proteomics. [published online October 24, 2019 ...

DOI: 10.7554/eLife.55289 Xin-Yan Zhang et al. Mu-Opioid Receptors Expressed in Glutamatergic Neurons are Essential for Morphine Withdrawal, Neuroscience Bulletin (2020). DOI: 10.1007/s12264-020 ...

April 2, 2009 — Long-term use of opioids to manage chronic pain increases patients' sensitivity to certain types of pain, and similar hyperalgesia develops with methadone-maintained drug abusers ...

Opioid-induced hyperalgesia (OIH) and allodynia; consider decreasing dose of current opioid or opioid rotation if OIH is suspected. Adrenal insufficiency.

Nociceptin (also called orphanin FQ) is an endogenous heptadecapeptide that activates the opioid receptor-like 1 (ORL1) receptor. Nociceptin system not only affects the nociception and locomotor ...

Review Article Published: April 2010 Adverse effects of chronic opioid therapy for chronic musculoskeletal pain Leslie J. Crofford Nature Reviews Rheumatology 6, 191–197 (2010) Cite this article ...

FDA staff noted that dropout during a 12-month trial could be the most challenging aspect of evaluating the long-term efficacy of opioids. "Our prior experience suggests a substantial dropout rate ...