Defining the COX Inhibitor Selectivity of NSAIDs: Implications for Understanding Toxicity Kathleen M Knights; Arduino A Mangoni; John O Miners Disclosures Expert Rev Clin Pharmacol. 2010;3 (6):769 ...

Tremeau’s lead clinical stage product, TRM-201 (rofecoxib), is a COX-2 selective NSAID and a potent non-opioid analgesic with a well-established benefit-risk profile.

Two new review studies evaluating the safety of the pain-relieving medications selective cyclooxygenase 2 (COX-2) inhibitors and non-steroidal anti-inflammatory drugs (NSAIDs) find increased ...

The increased risk for ibuprofen was 24% and for the now withdrawn selective COX-2 inhibitor rofecoxib was 32% (both p < 0.05). [22] ...

Although COX-2-selective drugs generally cause fewer gastric ulcers than non-selective NSAIDs, these events aren't completely eliminated, and the residual side-effect rate still may be high," said ...

The use of COX-2 selective inhibitors reduces the risk of upper gastrointestinal clinical events, compared with NSAIDs, in patients taking PPIs or low-dose aspirin; however, this result was driven ...

They searched for randomized controlled trials comparing the risk of GI adverse effects in patients taking nonselective NSAIDs, selective cyclooxygenase (COX)-2 inhibitors, or nonselective NSAIDs ...

“Tremeau is developing TRM-201 (rofecoxib), a COX-2 selective NSAID, as a potential treatment option for people living with pain whose needs are not satisfied by traditional NSAIDs,” Dr. Boice ...

However, multiple studies have indicated an increased risk of cardiovascular disease (CVD) complications from COX-2 selective NSAIDS, particularly in patients with prior CVD or risk factors for CVD.

FDA is collecting and will be analyzing all available information from the most recent studies of Vioxx, Celebrex, Bextra, and naproxen, and other data for COX-2 selective and nonselective NSAID ...

For example, celecoxib, a selective cyclooxygenase (COX)-2 inhibitor, has shown benefits for osteoarthritis in vitro without affecting healthy cartilage. The anti-inflammatory function of NSAIDs ...

Users of NSAIDs within the previous 14 days had a 19% higher risk for HF hospitalization compared with those who used NSAIDs more than 183 days in the past (adjusted OR = 1.19; 95% CI, 1.17-1.22 ...